An improved synthesis and mechanism study of magnetic Fe3O4@PGMA microspheres

• 作 者: ShujuanJiang;YuhaoHong;LeijiZhou;
• 机 构: Department of Chemistry,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 36100
• 出 处: 第八届全国微全分析系统学术会议、第三届全国微纳尺度生物分离分析学术会议暨第五届国际微化学与微系统学术会议
• 发表日期: 2013年期

　　Magnetic polyglycidyl methacrylate (Fe3O4@PGMA) microspheres have potential to build the sensitive elements of bead array and are suitable for biological application due to their surface hydrophilicity,biocompatibility and nonspecific adsorption.In previous work,magnetic microspheres were usually prepared using magnetic nanoparticles (MNPs) that were made by coprecipitation.But those MNPs cannot disperse uniformly in reaction system during synthesizing microspheres.Here we present an improved method to synthesize monodisperse superparamagnetic polymer microspheres using alcohol soluble Fe3O4 nanoparticles by dispersion polymerization.Instead of precipitation,the alcohol soluble Fe3O4 nanoparticles were obtained by reducing FeCl3 in polyols in the presence of sodium acetate [1].Using the improved method,the bulk of Fe3O4@PGMA microspheres were easily synthesized by one-pot with smooth and compact surfaces and had an average diameter of 3.5μm with excellent monodispersity (PDI 1.17),as shown in Fig.1.Further,the mechanism of synthesis is discussed (Fig.2).