【摘 要】
:
Human Cripto-1 is a cell surface protein belonging to the EGF-Cripto-FRL-1-Cryptic (EGF-CFC) gene family that has been shown to play key roles in embryonic development and in tumor progression.CRIPTO-
【机 构】
:
Prima Biomed Ltd Australia
论文部分内容阅读
Human Cripto-1 is a cell surface protein belonging to the EGF-Cripto-FRL-1-Cryptic (EGF-CFC) gene family that has been shown to play key roles in embryonic development and in tumor progression.CRIPTO-1 antibodies have been classified into 4 groups according to their ability to recognize different domains of the Cripto-1 protein in an ELISA assay: (1) N-terminal tip, (2) N-terminal, (3) EGF domain and (4) CFC domain.
其他文献
Due to its great contribution to the turnout cell survival, proliferation, and motility, epidermal growth factor receptor (EGFR) is, up to date, the most important therapeutic target of epithelial-ori
The American Society of Clinical Oncology and College of American Pathologists (ASCO/CAP) currently define HER2 positivity by immunohistochemistry (IHC 3+: uniform intense membrane staining of >30% of
Background: Cells released from the primary tumor persisting and recirculating in the host can lead to the formation of distant metastases.It was claimed that such cells are detectable only in a minor
Albeit not investigated in randomized studies systemic corticosteroids are the mainstay therapeutic regimens for this idiopathic inflammatory muscle disorder with most characteristic skin symptoms.Com
Objective To study atheroslerosis in systemic lupus erythematosus in relation to traditional and non-traditional risk factors for cardiovascular disease (CVD) including atheroprotective natural antibo
Endogenous retroviruses in the human DNA probably result from an exogenous infection of germ line cells during primate evolution nearly 25 million years ago.ERV-W copies are present in old world monke
ACCEPT, a randomized, active-controlled study, compared the efficacy of etanercept and ustekinumab in 903 patients with moderate-to-severe plaque psoriasis through wkl2.Skin biopsies were performed in
Since the introduction of the first biologic therapy for rheumatoid arthritis just over a decade ago, 9 drugs have been approved for registration, including 5 TNF inhibitors.Their general acceptance a
Alzheimers disease (AD) is the most common neurodegenerative disorders.Amyloid β-protein (Aβ) has been recognized as the leading cause of AD, and Aβ oligomer plays an important role in the early stage
Elevated serum IgE is a hallmark of allergic diseases such as asthma, and the neutralization of serum IgE in moderateto-severe allergic asthmatics using a therapeutic monoclonal anti-IgE antibody sign