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Aim: The cells of Human and mammalian perceive low oxygen concentration through hypoxia-inducible factor-1(HIF-1) that is binding protein of DNA.HIF-1 induces the transcription and expression of 60 proteins,including erythropoietin, vascular endothelial growth factor, glycolytic enzymes and so on.In response to hypoxia,the production of red blood cell (RBC) and augment of maximal oxygen uptake (VO2max) might be not only very beneficial for adapting to hypoxia, but also improved hypoxia training effects.Recently, a single nucleotide polymorphisms of C1772bpT found in human HIF-lα gene were shown to cause amino acid substation within or near the N-terminal transactivation domain, which enhanced transcriptional activity of HIF-1 α under nomoxia and hypoxia conditions.The physiological function of Human endothelial nitric oxide synthase gene (eNOS)synthesize NO.The NO can increase partial blood flux volume and supplementary of oxygen through regulating stretch of vessels and modulating blood pressure.These effects of NO seem to be essential for the beneficial effects of endurance training.There is a 27-base pair (bp) variable number of tandem repeat polymorphism (VNTR),4b/a (b equalling to repeats of 5, a equalling to repeats of 4), in the intron 4 of eNOS gene that was significant relativity with adaptation to hypoxia and physical activity.In human, the individual response to hypoxic training displays widely.And, some studies reported that the individual variation of human in acclimatization and physical activity under hypoxic circumstance had relationship with the genetic polymorphisms.The present study, therefore,investigated association between polymorphisms of HIF-1α, eNOS genes and individual variation in response to intermittent hypoxia training.Methods: We chose 41 health subjects, who performed 4 wk hypoxia training, to observed the relationship between C 1772T polymorphism in exon 12 of HIF-1 α gene and 27-base pair (bp) variable number of tandem repeat polymorphism(VNTR), 4b/a, in intron 4 of eNOS gene and physiological parameters,such as VO2max, Hb, RBC and SpaO2.Results: Our results showed that the change of O2 max was higher in carriers with CT genotype and combine genotypes of CT and ba than in others, respectively P=0.029, P=0.027,and the changes of Hb and RBC indicated higher tendency in the subjects carrying the CT genotype.Same results were observed in the changes of SpaO2 during period of exercising under hypoxic condition.Conclusion: We concluded that these, C1772T polymorphism of H1F-1α gene and 27-base pair (bp) variable number of tandem repeat polymorphism of eNOS gene, were possible relation to individual ability adapting to hypoxia and effect of hypoxia training in human.