Coactivators in Breast Cancer Disease Progression:SRC-1 Interactions with HOXC11

• 作 者: MMcIlroy;DMcCartan;AHill;LeonieYoung;
• 机 构: Department of Surgery Royal College of Surgeons D Blin Ireland
• 出 处: BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
• 发表日期: 2009年期

　　The development of an endocrine therapy resistant breast tumour is due, at least in part, to a shift in cancer cell phenotype from steroid to growth factor dependency.We have previously shown SRC-1 involvement and interaction with non-steroidal receptors suggesting that this protein may be a key mediator of growth-factor dependent breast cancer growth in tumours no longer solely regulated by steroids.This fits in with current thinking on SRC-1s role in promoting growth via ligand-independent mechanisms and its recently identified role in the promotion of metastasis.Identification of novel transcription factor hosts for SRC-1, significant in the endocrine resistant phenotype, would provide important information regarding the role of SRC-1 in the development of tumour recurrence and development of a steroid independent phenotype.In this study we employed a MS-based screen to isolate proteins which could differentially interact with SRC-1 in an endocrine resistant versus endocrine sensitive environment.