【摘 要】
：
To research the relationship between single nucleotide polymorphism within promoter region of three cytokine gene (TNF-α IL-1 β and IL-10) and the susceptibility to lung cancer, we conducted a populat
【机 构】
：
Department of Molecular Biology for Public Health, Shanghai Center for Disease Control and Preventio
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
To research the relationship between single nucleotide polymorphism within promoter region of three cytokine gene (TNF-α IL-1 β and IL-10) and the susceptibility to lung cancer, we conducted a population based case-control study in 132 healthy controls and 86 lung cancer patients.Genotyping for TNF-α-308、 IL-1 β-511 and IL-10-1082 was determined by real-time PCR.No significant difference in the genotypes distribution and allele frequencies of TNF-α IL-1 β and IL-10 polymorphism is found between overall case and control groups.Stratification analysis by smoking status and pathological types found that, there is significant differences in the distribution of TNF-α-308 G allelotype in the non-smoking subgroups(P=0.032, adjusted OR=9.581, 95% CI=1.211 ~75.824), also in the control groups and NSCLC subgroups (P =0.028, adjusted OR=5.182, 95% CI=1.198~22.414); Within the population carrying C allele in IL-1β-511, the distribution ofallelic frequencies between smoking subgroup and non-smoking subgroup is significantly different.TNF-α-308、 IL-1 β-511 and IL-10-1082 are not associated with the risk of lung cancer in overall Chinese Han population.However, the TNF-α-30g G allele is a risk factor for the occurrence of non-small cell lung cancer (NSCLC) and promotes the development of lung carcinogenesis in non-smoking population.Within the population carrying C allele in IL-1 β-511,-511 C allele is a protective effect against lung cancer in smoking population.
其他文献
Prostate cancer is the common cancer affecting men and has a high tendency to metastasize making it a very difficult to treat if not early detected.The survival and growth of prostate cancer cells are
Asymmetry along an apical-basal axis or apical-basal polarity within neural stem cells (NSC) is critical for the asymmetric segregation of cell fate and differentiation.NSC-derived differentiating dau
Gene expression profiling within pathologically defined malignancy uncovers new categories of cancer classes, including head and neck squamous cell carcinomas (HNSCC).Genome-wide cDNA microarray profi
Background: The mechanisms underlying chromosome instability (CIN) during cancer development are poorly understood.Recent data have shown that genomic instability can be triggered by cell fusion, whic
Adjuvant chemotherapy of cisplatin plus vinorelbine had showed a survival benefit over observation alone in a randomized trial ofNCIC JBR10 with 482 patients with Stage IB and Stage Ⅱ NSCLC (NEJM 2005
The aetin cytoskeleton is an appropriate target for general metastasis treatment because actin assembly, in particular, cortical actin assembly, is necessary for all the tumor associated movements, in
The team approach is a time-tested method for guiding new biologics or chemical entities through the early stages of drug discovery-before the drug is at a stage for testing in man, and drug developme
Astragali Radix is widely used in daily foods as a tonic supplement.Hedysarum polybotrys is one species of Astragali Radix.In this study, the immunomodulatory properties ofH.polybotrys were explored b
In recent years, near-infrared spectroscopy (NIRS) as a novel approach for cancer diagnosis has attracted much attention.In this study, NIR spectra of 77 endometrium sections (malignant, hyperplasia a
Variation in the human genome sequence plays a powerful but still poorly understood role in the etiology of common medical conditions.To learn the association ofa polymorphism with any disease, the fi