【摘 要】
：
The Eph receptors,the largest family of receptor tyrosine kinases composed of 14 members,play an essential role in the development of multicellular organism
【机 构】
：
Singapore,NationalUniversityofSingapore
【出 处】
：
2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)
论文部分内容阅读
The Eph receptors,the largest family of receptor tyrosine kinases composed of 14 members,play an essential role in the development of multicellular organisms by functioning at the interface between pattern development and morphogenesis,such as axon guidance,cell migration,segmentation,and angiogenesis.The signaling network mediated by Eph receptors and their ligand ephrin is conserved among metazoans.So far eight mammalian ephrins have been identified,which can be grouped into two structural and functional families,ephrinA and ephrinB.EphrinB and their Eph receptors are all plasma membrane-anchored proteins and are unique in their ability to transmit signals bidirectionally,thus mediating contact-dependent cell-cell interactions for guidance and assembly of cells.
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