【摘 要】
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Aiming at noninvasive,on-demand,and sustained antithrombotic therapy,a new thrombolysis approach based on the transgene system has been developed to remotely and precisely control the expression of ur
【机 构】
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MOE Key Laboratory of Analytical Science of Food Safety and Biology,College of Chemistry,Fuzhou Univ
论文部分内容阅读
Aiming at noninvasive,on-demand,and sustained antithrombotic therapy,a new thrombolysis approach based on the transgene system has been developed to remotely and precisely control the expression of urokinase plasminogen activator(uPA)by bioengineered cells for antithrombotic therapy both in vitro and in vivo.In this design,the near-infrared(NIR)light could activate the expression of the thermosensitive transient receptor potential vanilloid-1(TRPV1)channel in response to photothermal responsive nanotransducers to trigger the synthetic signaling pathway to secret uPA.By encapsulating bioengineered cells in injectable hydrogel to ensure long-term survival and convenience for injection,the engineered cells could noninvasively and precisely control the production of uPA protein in situ via an NIR laser to significantly enhance the thrombolysis therapeutic effects by spatiotemporally controlling the local temperature,in both the microfluidic blood circulation mimic and the murine tail thrombus model[1-2].
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