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  5. Functional variant 25566340 T > C polymorphism in DNMT3A promoter associated with gastric cancer

Functional variant 25566340 T > C polymorphism in DNMT3A promoter associated with gastric cancer

来源 :22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会) | 被引量 : 0次 | 上传用户：wcl929156
【摘 要】
：
Objective: To investigate associations between potentially functional tagSNP in the DNMT3A promoter region and susceptibility to gastric cancer risk inJiangsu population.Methods: We employed a haploty
【作 者】
：
Hua-Zhang Wu Feng-Chang Qiao Zheng-Hao Zhang Cheng-Cheng Zhao Hong Fan 
【机 构】
：
Institute of Life Science and Key Laboratory of Developmental Genes and Human Diseases,Ministry of E
【出 处】
：
22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
【发表日期】
：
2013年7期
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Objective: To investigate associations between potentially functional tagSNP in the DNMT3A promoter region and susceptibility to gastric cancer risk inJiangsu population.Methods: We employed a haplotype-based tagging SNPs(tagSNPs) approach (http://gvs.gs.washington.edu/GVS/and http://snpifo.ninehs.nih.gov/) and Haploview software from the HapMap and dbSNP database for the Chinese to identify tagSNP (25566340 T ＞ C) in the promoter region of DNMT3A.The transcription factor binding region at 25566340 T ＞ C was analyzed using an online search program (http://mbs.cbrc.
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