【摘 要】
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Background, Motivation and Objective A potential application of High Intensity Focused Ultrasound (HIFU), guided by either diagnostic ultrasound or MRI, is the ablation of tumor cells in abdominal org
【机 构】
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Imaging Division, UMC Utrecht, Utrecht, Netherlands
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Background, Motivation and Objective A potential application of High Intensity Focused Ultrasound (HIFU), guided by either diagnostic ultrasound or MRI, is the ablation of tumor cells in abdominal organs. A major challenge for this particular application is that the volumetric ablation rate, using current clinical equipment and sonication protocols operating below the stable cavitation pressure regime, is generally low in these high-perfused organs. Sonication strategies making use of shockwaves, millisecond boiling, and cavitation have been evaluated pre-clinically to enhance the energy uptake in the target area. However, the complex nature of these mechanisms has so far limited their application in clinical practice. The goal of this study was to investigate, under MR guidance and clinical conditions, whether a thermal ablation protocol using shockwaves and millisecond boiling can be used to enhance the energy uptake in the treatment area and ablate a confluent region in a highly perfused organ (porcine liver).
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