【摘 要】
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Background, Motivation and Objective Intracerebral hemorrhage (ICH) accounts for 10-15％ of all stroke and is characterized by the bleeding and clotting in the brain caused by the rupture of blood vess
【机 构】
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Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
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Background, Motivation and Objective Intracerebral hemorrhage (ICH) accounts for 10-15％ of all stroke and is characterized by the bleeding and clotting in the brain caused by the rupture of blood vessels. Current treatment options include surgery and medication, both with high mortality and morbidity rate. MR-guided focused ultrasound (MRgFUS) is currently being investigated to improve ICH therapy. With MRgFUS applied outside the skull, the clot in the brain can be liquefied and aspirated with a needle, providing a faster minimally invasive treatment. Treatment times can be extensive (3 hours to drain ≤40 mL clot) and cannot treat clot volumes larger than 40mL. Tissue within 2 cm of the skullcap cannot be treated. Transcanial histotripsy can overcome all these limitations, In addition. this study evaluated the effect of frequency on transcranial histotripsy ICH treatment efficiency.
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