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The U(VⅥ)-magnetic ion-imprinted polymer (MIIP) with a uniform core-shell structure for the selective separation and preconcentration of U(VⅥ) was prepared by copolymerization of a ternary complex of uranyl ions with 4-vinylpyridine (4-VP) and acrylamide in the presence of 2,2oazobisisobutyronitrile.