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Fungal secondary metabolites (SMs) are structurally diverse natural compounds, which are thought to have a great potential not only for medical industry but also for chemical and environmental industries.Since the expansion of sequencing microbial genomes in the 1990s, it has been known that SM genes are far more plentiful in microbial genomes than was expected before sequencing.For most of the genes, we have no information about the conditions for their expression, thus, probably 90% or more of them have remained unexamined.