【摘 要】
：
Cardiovascular disease (CVD) and Major Depression (MDD) are two of the worlds leading health problems and they are highly interrelated.Repeated episodes of stress, anxiety, and depression can lead to
【机 构】
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Loyola University Stritch School of Medicine USA
【出 处】
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BIT`s 3rd Annual World Congress of NeuroTalk-2012(2012第三届国际神
论文部分内容阅读
Cardiovascular disease (CVD) and Major Depression (MDD) are two of the worlds leading health problems and they are highly interrelated.Repeated episodes of stress, anxiety, and depression can lead to a chronic pro-inflammatory status culminating in atherosclerosis and ultimately cardiovascular and cerebrovascular disease.Patients with MDD have higher levels of perceived stress compared to healthy controls.The harmful effects of chronic stress and depression on cardiovascular health have been documented for many years.Mental stress can result in a prolonged increase in aortic stiffness and can induce vascular stiffening even in young apparently healthy subjects with no traditional CVD risk factors.Psychological stress has been correlated with structural changes in arteries eventually leading to endothelial injury with atherothrombotic sequealae.Anxiety is a major risk factor for myocardial infarction (MI) and anxiety among initially healthy persons often predicts future acute MI or death due to cardiovascular disease, independent of other major risk factors.We conducted an open-label study comparing patients with MDD and matched healthy controls and sought to determine the level of stress perception before and after treatment with escitalopram.Additionally, we assessed the degree of inflammation and arterial stiffness present in our subjects at pretreatment and whether the depressed patients showed normalization of inflammation biomarkers and arterial stiffness following successful treatment with escitalopram.
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