Dual-Functional c(RGDyK)-Decorated Pluronic Micelles for Antiangiogenesis and Drug Resistant Tumor T

• 作 者: YanzuoChen[1]FengGao[2]XianyiSha[3]XiaolingFang[3]
• 机 构: Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Sh
• 出 处: 纳米药物及纳米生物技术国际学术大会暨中国药学会纳米药物专业委员会成立大会
• 发表日期: 2015年期

　　Dual-function drug delivery system was developed by decorated c(RGDyK) peptide with Pluronic micelles (c(RGDyK)-FP-DP) to overcome the drawbacks of low transport of chemotherapeutics across the blood-tumor barrier (BTB) and poor drug resistant tumor therapy, c(RGDyK) that can bind to the integrin proteins expressed on the site of tumor vascular endothelial cells and tumor cells with high affinity and specificity, was conjugated to the NHS-activated PEO terminus of the Pluronic copolymer.