Graves'病患者中CCL20的表达及骨桥蛋白对其调节机制的研究

来源 :中华医学会第十二次全国内分泌学学术会议 | 被引量 : 0次 | 上传用户:beibei114
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目的:检测GD患者与正常志愿者血浆中CCL20水平,探究CCL20作为GD小分子标志物的可能性,以及探索OPN在调节CCL20表达中的作用.方法:门诊筛选50名初发GD患者、15名甲功正常的GD患者、12名TRAb转阴的GD患者及35名正常志愿者作为研究对象,收集临床资料及外周血标本.CD4+T细胞通过免疫磁珠阳性分选的方法从PBMCs中获取.分别通过qPCR和ELISA的方法检测CCL20、IL-17 mRNA和蛋白水平的表达.
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