Hepatitis B virus (HBV),a small enveloped DNA virus,chronically infects more than 350 million people worldwide and causes liver diseases from hepatitis to cirrhosis and liver cancer.Here,we report tha
Genome editing via CRISPR/Cas9 has become an efficient and reliable way to make precise,targeted changes to the genome of living cells.CXCR4 is a co-receptor for the human immunodeficiency virus type
Hepatitis B virus(HBV)infection is one of the most serious and prevalent viral diseases in the world.Although several anti-HBV drugs have been used clinically,their side and adverse effects limit trea
NF-κB信号途径在天然免疫应答中扮演着重要的作用,而痘病毒明显的一个特点就是能抑制宿主的抗病毒反应,其中包括了NF-κB信号通路.NF-κB是核转录因子,隐藏在细胞质中,当细胞受到刺激后,NF-κB就被激活了,NF-κB抑制剂IκBα蛋白的降解依赖SCF(Skp1,culllin-1,F-box)泛素连接酶,IκBα蛋白与SCF的结合通过F-box结构蛋白βTrCP.
EIAV(马传贫)病毒与HIV病毒同属于逆转录病毒科慢病毒属,马传贫弱毒疫苗是目前世界上唯一成功应用的慢病毒疫苗,对于该疫苗作用机制的阐明将为艾滋病疫苗的研究提供借鉴.在基础研究和临床检测中,病毒载量的定量分析至关重要,以往对EIAV的检测方法有基于探针的荧光定量PCR,敏感特异,但价格昂贵;还有的方法因需要感染细胞或者测量量子点发射峰等,使得操作技术要求高、实验时间长而未得到广泛的应用,因此,急
TRAF family member-associated NF-κB activator (TANK) is a negative regulator of canonical NF-κB signaling in the Toll-like receptor (TLR)-and B-cell receptor (BLR)-mediated signaling pathways.However,
Oxidative stress has been reported to induce the activation of signal transducer and activator of transcription 3(STAT3),which plays an important role in hepatocellular carcinoma(HCC).We have previous
There is limited information about the role of cervical epithelial cells in genital innate immunity against herpes simplex virus type 2(HSV-2)infection.We thus examined whether human cervical epitheli
Background: The Bowman-Birk inhibitor(BBI)is a soybean-derived protease inhibitor that has anti-inflammatory effect in both in vitro and in vivo systems.Inflammation and immune activation are believed
Bluetongue virus(BTV),a nonenveloped double-stranded RNA virus,is a potent inducer of type Ⅰ interferons in multiple cell systems.In this report,we present that BTV16 treatment of primary human macrop