【摘 要】
：
Malignant tumors are widely spread in humans and they form a serious medical and social burden.Despite of the progress in cancer therapy, the prognosis of m
【机 构】
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Faculty of Medicine Charles University in Prague Institute of Anatomy and Center of Cell Therapy and
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Malignant tumors are widely spread in humans and they form a serious medical and social burden.Despite of the progress in cancer therapy, the prognosis of many patients does not seem to be optimistic.Remarkable achievements in stem cell research delineated new horizons of possible future improvement of cancer therapy.Paradigm of existence of cancer stem cell has been established in solid tumors and it is based on parallel between tissue stem cells and population of cancer cells responsible for tumor spreading.Normal tissue stem cells require highly specialized microenvironment, niche that is necessary for the maintenance of their sternness; disorders of such microenvironment drive the stem cell population to entrance to the process of final differentiation.
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