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Various physiological rhythms strongly influence cognitive performances by means of changing brain oscillations, especially the theta and gamma rhythms.In this study, we investigated the coupling relationship of neural activities between thalamus and medial prefrontal cortex (mPFC) by evaluating the phase interactions between theta and gamma oscillations in depression model of Wistar rats.Our data showed that phase synchronization at theta rhythm was weakened.Theta-gamma phase locking at n∶m (1∶6) ratio was found between thalamus and mPFC in normal state, but diminished in depression state.In addition, the unidirectional influence from thalamus to mPFC was reduced in depressive rat model only in theta rhythm, which was enhanced after memantine treatment.The results suggest that the effects of depression on cognitive deficits are modulated via profound alterations in phase information transmission of theta rhythm and theta-gamma phase coupling.