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Chemotherapy has long been one of the major therapeutic approaches for cancer treatment.However,the traditional chemotherapeutic approaches often exhibit insufficient therapeutic efficacy and adverse side effects due to the systemic nature of standard drug administration,the nonspecific delivery of drugs,and lack of control over the drug release profiles1.A unique way to enhance the chemotherapeutic efficacy while minimizing the damage of healthy tissues is to use deliberately designed nanoconstructs as stimuli-responsive drug vehicles for site-selective targeting of tumorigenic cells and controlled on-demand release of the drugs2,3.