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Liposomes have already had a major impact on improving the druggability,especially the application in antitumor drugs.Liposome-based drugs carved out a sizeable share of anticancer nanomedicines clinical trials and the market.The greatest challenges for the development of liposomes are their poor stability and single-function nature during assembly and in vivo delivery process.The multifunctional liposomes,which are able to overcome multiple physiological barriers,stabilize and improve biodistribution of therapeutic angents to target sites in vivo,would be highly desirable.