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The aim of this study was to investigate the early changes in coagulation functions in patients with different degrees of Acute Pancreatitis (AP).Data from a total of 133 AP patients was studied.The differences in the Prothrombin Time (PT),Activated Partial Thromboplastin Time(APTT),Fibrinogen Concentration (FIB),International Normalized Ratio (INR),and serum Ca2+ levels among different groups,and their relationships to the Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ score were compared.FIB in the Moderately Severe Acute Pancreatitis (MSAP) group was significantly higher than the Control Group (CG),and the Mild Acute Pancreatitis (MAP) group (P<0.0S).Ca2+levels in the MSAP group were lower than in the control and MAP groups (P<0.05).PT,APTT,and INR in the Severe Acute Pancreatitis (SAP) group were higher than in the control,MAP,and MSAP groups(P<0.05).FIB in the SAP group was higher than in the control and MAP groups (P<0.05),and Ca2+ levels in the SAP group were lower than in the control,MAP,and MSAP groups (P<0.05).The APACHE Ⅱ score in the MSAP group was higher than in the MAP and control groups (P<0.05),and higher in the SAP group than in the MSAP,MAP,and control groups (P<0.05).Ca2+ levels and the APACHE Ⅱ score were negatively correlated in the MSAP group.In the SAP group,FIB was positively correlated with the APACHE Ⅱ score,but Ca2+ levels were negatively correlated with them.In the classification of acute pancreatitis,FIB and Ca2+levels are associated with the severity of pancreatitis.Patients with early AP show different levels of coagulation dysfunction,which is much more pronounced in patients with MSAP and SAP.