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Objective To investigate the drug resistance of Escherichia coli in liver cirrhosis combined with spontaneous bacterial peritonitis (SBP),and provide the credible evidence with the clinic diagnosis and the treatment of SBP.Methods Totally 115 cases of hospitalized cirrhotic patients with the clinic diagnosis to our hospital between Jan,2006 and Dec,2010.Ascitic fluids of all cases were cultured.The pathogens was identified and the drug resistance was analyzed.