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Background: There are continuing debates regarding possible risk to participants of suicide-related research.Can asking someone if they feel suicidal, or about their past suicidal behaviours, produce distress or even suicidal feelings and behaviours? The few previous studies in this area have provided some evidence that suicide-related research is generally safe.However, the findings have been far from conclusive.Methods: This study was conducted to test whether asking questions about suicide might produce psychological distress in some participants.A randomized double-blind design, with between-groups (experimental and control groups both n > 100) and within-groups assessment, as well as post-survey follow-up.Results: The findings shed new light on how suicide-related research affects participants.The results explore age, sex, ethnicity, suicide-risk, and psychological factors as they relate to participant risk.An additional contribution of the present study is the information gained on help-seeking behaviours of at-risk participants.Conclusion: Psychology research can affect some participants psychological distress.However, the findings suggest suicide-related research may be safe.Research implications will be thoroughly discussed.