Investigation of the Mechanism of β-Amyloid Fibril Formation byKinetic and Thermodynamic Analyses

来源 :第八届中国蛋白质组学大会 | 被引量 : 0次 | 上传用户：tandge

【摘要】

：

【作者】

：

Ming-Shen Lin Wen-Yih Che

【机构】

：

TA instruments-Waters LLC,Shanghai,China;Department of Chemical and Materials Engineering,National C

【出处】

：

第八届中国蛋白质组学大会

【发表日期】

：

2013年11期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Extracellular β-amyloid (Aβ) deposit is considered as one of the primary factors that induce Alzheimers disease(AD).The effects ofvarious environmental factors,including temperature,ionic strength,and pH,on Aβ(1–40)aggregation mechanisms were investigatedin this study by spectrometry,isothermal titration calorimetry (ITC),andhydrophobic fluorescence assay.

其他文献

Quantitation and Evaluation of Candidate Biomarkers of Pancreatic Cancer in Plasma using Multiple Re

Pancreatic cancer is one of the most highly aggressive and lethal of all solid malignancies.Systematically discovering and validatingnew biomarkers for early diagnosis of pancreatic cancer is under ur

会议

pancreatic carcinomaiTRAQserum

Nuclear phosphoproteome reveals that EGF Regulates Alternative Splicing through mTORC1 pathway in MD

Aberrant epidermal growth factor receptor (EGFR) signaling is a typical characteristic of many human malignancies.Emergingevidences suggest the two EGFR signaling pathways,located in cytoplasmic and n

会议

PhosphoproteomeiTRAQMDA-MB-468 cellEGFRapamycinAlternative splicing

Mechanism survey on Cell Senescence Induced by the knockdown of Cathepsin D through Quantitative Pro

Cathepsin D (Cath D) is one of the major proteases in the lysosome in eukaryotic cells.Various cell models have demonstratedthe enzymatic activity of cathepsin D is required to combat exogenous stress

会议

Quantitative proteomicsSILACLC-MSMSCathepsin DCellular senescenceRNAi

Functional Proteomics of Rice Plants in response to Salt Stress

A rice cyclophilin,OsCYP2,was identified in salt-tolerant rice by proteomic techniques.OsCYP2 not only had function of salttolerance,but also was involved in response to multiple stresses-drought,cold

会议

Functional proteomicsRiceSalt stresscyclophilinOsCYP2interacting proteins

Physiological and Proteomic Analysis of Salinity Tolerance in Germinating Seeds from Brassica napus

Soil salinity is a major abiotic stress that has a serious influence on seed germination.Studying salinity tolerance mechanism duringseed germination will provide valuable information for engineering

会议

Seed germinationBrassica napusProteomicsSalinity tolerance

Response of Maize Leaf Proteins Induced/Modulated by AM Mycorrhizal Inoculation and (or) Arsenic Str

In this paper,proteomics were performed to analyse the changes in leaf proteins in response to As additions and mycorrhizalinoculation.A targeted proteomic approach was used to determine the putative

会议

abuscular mycorrhizal fungiZea mayscomparative proteomicsAs stress

STEAP4 Downregulation Accelerates Liver Regeneration as a novel lipid Droplet Protein

Lipid droplets (LDs) are composed of a core of triacylglycerol surrounded by a monolayer of phospholipid,into which various lipiddroplet proteins (LDP) are embedded.Recently,more and more evidences ha

会议

Lipid Droplet ProteinSTEAP4liver regenerationProteomics

6-Shogaol Induces Apoptosis in Human Hepatocellular Carcinoma Cells through Endoplasmic Reticulum St

6-Shogaol is an active compound isolated from Ginger (Zingiber officinale Rosc).In this work,we demonstrated that 6-shogaolinduces apoptosis in human hepatocellular carcinoma cells(HCCs)in relation to

会议

human hepatocellular carcinoma cells6-shogaolendoplasmic reticulum stressPERK

NAD-Mediated Protein Expression, Cell Proliferation, and Responses to Oxidative Stress

Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells and mediates multiple cellular signaling pathways.However,mechanisms by which NAD influences gene regulation and cell pr

会议

CD38proteomicschaperonesoxidative stressglycolytic enzymes

UNG1 Complexes in Oxidative Stress and DNA Repair

Deamination of cytosine or incorporation of dUMP during DNA replication leads to uracil incorporation and DNA damage.Uracil-DNAglycosylase (UNG) is a base excision repair enzyme that participates in r

会议

DNA repairOxidative stressUNG1Protein complexSILACQuantitative proteomics

Investigation of the Mechanism of β-Amyloid Fibril Formation byKinetic and Thermodynamic Analyses

其他学术论文