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Numerical investigation has been carried out to study the flow mal-distribution in a flow channel which is connected with a sirocco fan.The simulation results showed a good agreement with experimental data.The standard deviation (S) of the flow rate was employed to define the uniformity of the flow distribution.According to the simulation result,the arrangement of the reference guide vane degrades the flow uniformity of the flow channel.Several new arrangements of guide vanes are tested through the numerical simulations.Based on these results,the distribution uniformity of the horizontally arranged guide vane is preferred.When comparing with the reference arrangement,the flow uniformity of horizontal arrangement was enhanced by 15.6%.