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Objective: Inhibition of Rho-kinase displays property against cardiac remodeling, although its effect on has not been fully elucidated.The present study was designed to investigate the impact of fasudil, a Rho kinase inhibitor, on cardiac and plasma Angiotensin Ⅱ (Ang Ⅱ) and Angiotensin (1-7) (Ang (1-7)) in pressure-overload Rats.