Preparation and characterization of eudragit L100 microcapsules containing zinc gluconate

• 作 者: LUOLijuan[1]HUYanchun[1]FUHualin[1]LUOBiao[1]QIAOYan[1]LIUXi[2]LANLan[2]DENGShijin[2]ZUOZhicai[1]DENGJunliang[1]JIANGZhongrong[2]
• 机 构: College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014 China
• 出 处: 中国畜牧兽医学会兽医内科与临床诊疗学分会2014年学术研讨会及小动物临床技术交流会
• 发表日期: 2014年期

　　Eudragit L100 microcapsule was prepared to encapsulate zinc gluconate trihydrate (zinc gluconate)using emulsion solvent evaporation method and the optimum condition was investigated by response surface methodology (RSM) analysis in order to improve the bioavailability of oral zinc preparations.The drug-loading rate (DL) of the microcapsules was detected by flame atomic absorption spectrophotometer, and the drug release property in vitro and some other characteristics were studied.The results showed that the optimum preparation conditions for Eudragit L100 microcapsules based on encapsulation efficiency (EE) were :0.64 g zinc gluconate,125 ml liquid paraffin, 1.26 g talcum powder and 2.57 g span-80.Prepared microcapsules had round and smooth surface,uniform diameter distribution of 250 μm, DL of 17.97% and EE of 93%, and the release rate of zinc gluconate from microcapsules in vitro conformed to the standard of enteric preparation.In conclusion, the preparation method is reliable and simple,and comprehensive evaluation of the microcapsules is good,which provide a reliable basis for clinical applications research.