【摘 要】
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Introduction:Mesenchymal stem cell (MSC)-based therapies have had positive outcomes both in animal models of cardiovascular diseases and in clinical patients.However, the number and function of MSCs d
【机 构】
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Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment,The Second Af
【出 处】
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Ready for 2018- the 4th China International Forum on Hyperte
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Introduction:Mesenchymal stem cell (MSC)-based therapies have had positive outcomes both in animal models of cardiovascular diseases and in clinical patients.However, the number and function of MSCs decline during hypoxia and serum deprivation (H/SD), reducing their ability to contribute to endogenous injury repair.MicroRNA-34a (miR-34a) is originally identified as a TP53-targeted miRNA that modulates cell functions, including apoptosis, proliferation, and senescence via several signaling pathways, and hence is an appealing target for MSC-based therapy for myocardial infarction.
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