An Efficient One-Pot Synthetic Approach to Pyrrolo[4,3,2-de]quinolinones

来源 :中国化学会全国第十二届有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户：z4360877

【摘要】

：

　　Pyrrolo[4,3,2-de]quinoline core is a characteristic substructure found in a number of natural products which often exhibit a wide range of biological activi

【作者】

：

YangChangjiang;HeZhengjie;

【机构】

：

The State Key Laboratory of Elemento-Organic Chemistry and Department of Chemistry,Nankai University

【出处】

：

中国化学会全国第十二届有机合成化学学术研讨会

【发表日期】

：

2015年期

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　　Pyrrolo[4,3,2-de]quinoline core is a characteristic substructure found in a number of natural products which often exhibit a wide range of biological activities.[1] For example,an array of newly discovered marine alkaloids ammosamides[2] with such fused cyclic skeleton possess attractive bioactivities including significant cytotoxicity against human HCT-116 colon carcinoma and moderate inhibitory potency against human quinone reductase.

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An Efficient One-Pot Synthetic Approach to Pyrrolo[4,3,2-de]quinolinones

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