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Surgical resection offers hepatocellular carcinoma (HCC) patients a chance for a cure, but carries a high tumor recurrence rate.Clusterin is a highly conserved glycoprotein, enhancing cell aggregation in vitro.Clusterin upregulated in cancers of the breast, ovary, colon, prostate, kidney and HCC.Overexpression of clusterin has been correlated with tumor metastasis.This study evaluates the significance of serum clusterin levels and protein expression in resected tissue specimen in HCC patients.