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To widen the application of garlic polysaccharide (GP),the reaction between GP and octenylsuccinic anhydride (OSA) was investigated in water at pH 8.0~8.5.The obtained octenylsuccinic garlic polysaccharide (OSA GP) was dialysised and lyophilized.The OSA GP(A) degree of substitution was 0.0117.The carbonyl vibrations absorption peaks (C=O 1729.25 cm-1),the ethylene vibrations absorption peaks (C =C 1576.97cm-1) were identified by IR spectrum.These results have shown that the OSA GP was created successfully