Expression and significance of SOCS-3 and STAT-3 in endometriosis

• 作 者: Ruan F Tu FX Xu KH Wu RJ Ma JY Zhan H Lin J
• 机 构: Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University,
• 出 处: 2013年浙江省微创外科学学术年会
• 发表日期: 2013年4期
• 关键词: Endometriosis Suppressor of cytokine signaling-3 Signal transducer and activator

　　To investigate the expression of suppressor of cytokine signaling-3 (SOCS-3) and signal transducer and activator of transcription-3 (STAT-3) in the ectopic and eutopic endometria from women with endometriosis, and explore their relationship with endometriosis.Thirty-two ectopic and eutopic endometrial tissues from women with ovarian endometriosis and thirty control endometrial tissues from women without endometriosis undergoing surgery for benign gynaecological diseases were collected for immunohistochemical analysis.Western blot analysis was performed to further detect the quantitative expression of SOCS-3, STAT-3 and phosphorylated STAT-3 (p-STAT-3) proteins in thirty women with endometriosis and twenty-five women without endometriosis.Significantly higher expression of p-STAT-3 protein and lower expression of SOCS-3 protein were found in the ectopic endometrium than those of eutopic endometria (P<0.001) and control endometria (P<0.001).Moreover, the expression of SOCS-3 was correlated with the stages of endometriosis (P<0.001).The present study suggested that high activation of STAT-3 and low expression of SOCS-3 had close relationship with endometriosis ,which may be involved in the pathogenesis and progression of this disease.