Developing Novel Mass Spectrometric Tools to Identify Post-translational Modifications and Sequence

来源 :2011第三届中国北京抗体大会 | 被引量 : 0次 | 上传用户：dza1987

【摘要】

：

Recombinant monoclonal antibodies can be heterogeneous due to modifications that can occur during expression, purification or storage.These large multi-chain proteins are structurally challenging for

【作者】

：

Jennifer Zhang Viswanatham Katta

【机构】

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Scientist Protein Analytical Chemistry Genentech Inc. USA

【出处】

：

2011第三届中国北京抗体大会

【发表日期】

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2011年1期

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　　Recombinant monoclonal antibodies can be heterogeneous due to modifications that can occur during expression, purification or storage.These large multi-chain proteins are structurally challenging for detailed characterization to identify the sites of modifications.Mass spectrometry has played key roles in assessing protein primary structure with high degree of details.

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