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A systematic and undirected biomarker discovery approach has been implemented, utilizing array-based platforms and the massive antigen and antibody production pipeline within the Human Protein Atlas.Proteomic profiling of multi-disease serum, plasma and CSF cohorts are performed with large numbers of antigens on planar microarrays and furthermore with large numbers of antibodies on highly multi-parallel suspension bead arrays which utilizes microtiter plates and magnetic color-coded beads functionalized with antibodies to generate protein profiles from labelled samples.