【摘 要】
：
Oxygen saturation in cutaneous microvessels has a great potential for the characterization of skin physiology.However because of the high scattering property of skin,just using the hyperspectral imagi
【机 构】
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Britton Chance Center for Biomedical Photonics,Wuhan National Laboratory for Optoelectronics,Huazhon
【出 处】
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2015年中国生物医学工程联合学术年会
论文部分内容阅读
Oxygen saturation in cutaneous microvessels has a great potential for the characterization of skin physiology.However because of the high scattering property of skin,just using the hyperspectral imaging(HSI)technique,the maps of oxygen saturation in cutaneous microvessels could not be obtained with satisfactory resolution.But the optical clearing techniques provides a new approach to reduce the scattering property of skin.Thus,in this work,the skin optical clearing techniques was employed to improve the performance of HSI for assessing blood oxygen of cutaneous microvessels,including the imaging resolution,contrast and sensitivity of blood oxygen dynamical response to hypoxia.In addition,the effectiveness of hyperspectral analysis was verified by Monte Carlo simulation.We also demonstrated that optical clearing agents(OCAs)had no significant effect on the blood oxygen of cutaneous microvessels.The hypoxia experiment demonstrated that during a hypoxic challenge there was a decrease in the oxygen saturation of venule and arteriole.Thus,the combination of skin optical clearing techniques and HSI provides a valuable way to monitor the changes of cutaneous microvascular blood oxygen with superior imaging performance under the physiological and pathological status.
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