CPG-ODN治疗辐射损伤的研究

来源 :第二届全球华人辐射研究大会 | 被引量 : 0次 | 上传用户：helen515

【摘要】

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【作者】

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蔡建明高福张超刘聪刘聪杨彦勇

【机构】

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第二军医大学放射医学教研室

【出处】

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第二届全球华人辐射研究大会

【发表日期】

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2014年10期

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近年来,Toll类受体(Toll-like receptors,TLRs)及其激动剂在抗辐射损伤中的防治作用正引起放射生物学界的高度重视,2008年,受到美国国防部和NIH (national institutes of health)资助的Cleveland生物实验室在Science 杂志上报道其研究的改良型TLR5激动剂CBLB502(一种沙门氏菌毛蛋白)具有极强的辐射损伤防护效应,结果显示即使在受照后2 h给予药物仍然有很好的减轻放射损伤效果[2].他们的发现无疑是近几十年来辐射损伤防治基础理论研究的一个十分重要的突破,为辐射损伤治疗研究开辟了一个新的领域.受此启发,2009年本实验室也开始对TLRs家族中其他成员及其激动剂在抗辐射损伤作用展开研究,其中包括TLR9激动CpG-ODN (oligonucleotides).

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CPG-ODN治疗辐射损伤的研究

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