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Ethnopharmacological relevance Hemorrhagic transformation is a frequent asymptomatic event that occurs after acute ischemic stroke, especially after pharmaceutical thrombolysis.However, the mechanism of hemorrhagic transformation and therapeutics were unknown.In this study, we combine administered astragalus membranaceus and ligustrazine in rats underwent cerebral ischemia with thrombolysis;and analyzed their effects on attenuation of hemorrhagic transformation,maintaining of blood-brain barrier integrity.