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Animals initiate different behaviors in respond to visual stimuli with distinct ecological meanings.However,despite abundant studies at visual processing level,little is known about its underlying neural mechanisms at visuomotor transformation stage.Here,using the visual escape circuit of zebrafish as a model system,we find that dopaminergic neurons in the caudal hypothalamus and specific clusters of glycinergic interneurons in the hindbrain form a functional module,which gates the visuomotor transformation in a stimulus-dependent manner.The dopaminergic neurons can activate the interneurons.Both of them are visually responsive and can regulate visual signal transfer from the visual center to the command neuron of escape behavior.In respond to flash,both the two types of neurons are activated,leading to blockade of visuomotor transformation.Instead,looming stimuli suppress the activity of these neurons,thus permitting visual signal to reach the command neuron and initiate escape behavior.Our study illustrates a novel gating mechanism underlying stimulus-selective visuomotor transformation.