Viral protein-repressed microRNA-148a controls tumor growth and metastasis through HPIP-mediated mTO

来源 :第一届自噬生物学与疾病国际研讨会(The 1st International Symposium on Autophag | 被引量 : 0次 | 上传用户：fly884531973

【摘要】

：

在病毒引发的相关肿瘤中miRNA的表达异常已有芯片数据报道,然而,在细胞内miRNA通过何种信号通路调控病毒相关肿瘤的发生和发展我们所知甚少.本研究发现miR-148a/HPIP/mTOR信号通路在调控病毒相关肿瘤的生长和转移的作用.我们首先发现HPIP为miR-148a的直接靶基因,miR-148a会降低HPIP的表达,其表达降低导致AKT和ERK通路的抑制,进而又抑制了在自噬中发挥重要作用的m

【作者】

：

徐小洁范忠义叶棋浓

【出处】

：

第一届自噬生物学与疾病国际研讨会(The 1st International Symposium on Autophag

【发表日期】

：

2015年9期

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