【摘 要】
：
Water-soluble conjugated polyelectrolytes(CPEs)contain π-conjugated backbones with ionic side groups and have demonstrated potential application in chemical and biological sensing.1 In recent years,co
【机 构】
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The Graduate School at Shenzhen,Tsinghua University,P. R. China
【出 处】
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2016年分析化学前沿国际研讨会及中美分析化学研讨会
论文部分内容阅读
Water-soluble conjugated polyelectrolytes(CPEs)contain π-conjugated backbones with ionic side groups and have demonstrated potential application in chemical and biological sensing.1 In recent years,conjugated polymer nanoparticles(CPNs)have emerged as a promising approach toward cell imaging due to their prominent properties,such as easy preparation and separation,low cytotoxicity,excellent photostability and good biocompatibility.2 Herein,Three anionic conjugated polyelectrolytes(CPEs)with poly(p-phenylene ethynylene thiophene)backbones were designed and synthesized,among which PPET3-CO2H showed the greatest molar extinction coefficient with red-shifted bands in both absorption and emission spectra compared to the well studied PPE polymer.PPET3-CO2H was thus chosen to construct CPE-based nanoparticles(CPNs)with octaarginine(R8)peptide throught electrostatic-interaction-induced self-assmebly.Based on the low cytotoxicity and efficient plasma membrane penetration,PPET3/R8 CPNs demonstrated its potential applications in apoptotic cell imaging in vivo.
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