【摘 要】
：
A growing body of work implicates chemokines,in particular CXCL12 and its receptors,in the progression and site-specific metastasis of various cancers,inclu
【机 构】
：
UniversityofAdelaideAustralia
【出 处】
：
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
A growing body of work implicates chemokines,in particular CXCL12 and its receptors,in the progression and site-specific metastasis of various cancers,including breast cancer.However,as a potent chemotactic factor for leukocytes,CXCL 12 also has the potential to enhance anti-cancer immunity.The aim of this study was to further elucidate the role of CXCL1 2 in breast cancer development and metastasis.To achieve this,wild-type CXCL12 and a CXCL12 antagonist,CXCL 12(P2G),were overexpressed in the 4T1.2 mouse model of breast carcinoma.
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