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  5. Activated mTOR/p70S6K pathway is involved in the cognitive dysfunction of STZ-induced diabetic rats

Activated mTOR/p70S6K pathway is involved in the cognitive dysfunction of STZ-induced diabetic rats

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：caonimalegebicaonima
【摘 要】
：
Aim: Hyperphosphorylation of tau mediated by mTOR/p70S6K pathway has been thought to contribute to cognitive dysfunction of Alzheimers disease.Whether mTOR/p70S6K signaling is also involved in cogniti
【作 者】
：
Shan WANG Ni FANG Shan-lei ZHOU Jin-ju MA Sheng-dian NIE Jing WU 
【机 构】
：
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central Sou
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
mTOR p70S6K tau cognitive dysfunction 
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Aim: Hyperphosphorylation of tau mediated by mTOR/p70S6K pathway has been thought to contribute to cognitive dysfunction of Alzheimers disease.Whether mTOR/p70S6K signaling is also involved in cognitive dysfunction of diabetes mellitus still remains unknown.Methods: The alteration of mTOR/p70S6K signaling and phosphorylated tau in the hippocampus of STZ-induced diabtetic rats was detected by Western blot at 10, 15, and 20 weeks after STZ injection.
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