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  5. Conflicts of DNA methylation and CpG density are involved in alternative promoter usage and genome s

Conflicts of DNA methylation and CpG density are involved in alternative promoter usage and genome s

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户：juyuyong
【摘 要】
：
The pattern of DNA methylation is shaped by different factors including CpG dinucleotide density.To globally evaluate the relationship between CpG density and DNA methylation,an algorithm was develope
【作 者】
：
Fushun Chen Chengjun Chen Qingzheng Zhang Dekang Lv Xiaodi Deng Zhiguang Li 
【机 构】
：
Center of Genome and Precision Medicine, Institute of Cancer Stem Cell, Dalian Medical University
【出 处】
：
第七届全国生物信息学与系统生物学学术大会
【发表日期】
：
2016年8期
【关键词】
：
DNA methylation Epigenome WGBS 
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　　The pattern of DNA methylation is shaped by different factors including CpG dinucleotide density.To globally evaluate the relationship between CpG density and DNA methylation,an algorithm was developed that includes multiple steps of gauchian transformation,lowess normalization,density-based rescaling,and peak findings.This algorithm was applied to multiple whole genome bisulfite sequencing methylomes including 36 adult human tissues and 50 mouse tissues of different development stages and tissue origins.
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