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  5. Identifying the Enriched Biological Pathways in Genes Related to Nicotine Dependence via a Network-b

Identifying the Enriched Biological Pathways in Genes Related to Nicotine Dependence via a Network-b

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户：zhgrmlshr
【摘 要】
：
Pathway enrichment algorithms are applied to detect biological pathways significantly related to a given set of genes associated with a specific disease or phenotype,experimental biology conditions.In
【作 者】
：
方忠海 杨一晨 胡莹 胡言石 
【机 构】
：
王举天津医科大学,生物医学工程与技术学院,天津300070
【出 处】
：
第七届全国生物信息学与系统生物学学术大会
【发表日期】
：
2016年8期
【关键词】
：
Network Gene Weights Over-Representation Analysis 
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　　Pathway enrichment algorithms are applied to detect biological pathways significantly related to a given set of genes associated with a specific disease or phenotype,experimental biology conditions.In the classical over-representation analysis,there is an apparent losing of inequality of genes within a defined pathway.Hence we developed a network-based method to determine such non-equivalence in accordance with gene weights,and integrated it into the fight-tailed Fishers exact test to measure the chance that the genes of interest participate in a given pathway.
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