【摘 要】
：
Schizophrenia and bipolar disorder are complex mental disorders,with risks contributed by multiple genes.Recently,genome-wide systemic approaches have been used to reveal the associations of hundreds
【机 构】
：
中南大学生命科学学院,医学遗传学国家重点实验室,长沙,410078 伊利诺伊大学芝加哥分校,精神病
【出 处】
：
第七届全国生物信息学与系统生物学学术大会
论文部分内容阅读
Schizophrenia and bipolar disorder are complex mental disorders,with risks contributed by multiple genes.Recently,genome-wide systemic approaches have been used to reveal the associations of hundreds of SNPs with those disorders.Dysregulation of gene expression has been implied,but little is known about such regulation systems in the human brain.By integrating gene expression data of rnRNA and microRNA (miRNA) obtained from the same brain collection of 51 cases and 24 controls using the weighted gene co-expression network analysis (WGCNA),we built mRNA-miRNA co-expression networks and detected modules differentially expressed between controls and patients of schizophrenia and bipolar disorder.In the disorder-associated modules,we identified the potential regulators,including transcription factors (TFs) and miRNAs,and their co-expressed protein-coding genes.
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