Esterase responsive charge-reversal vectors for gene delivery and therapy

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：yifeng9131120

【摘要】

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【作者】

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Nasha Qiu Xiangrui Liu Ying Piao Zhuxian Zhou Jianbin Tang Youqing Shen

【机构】

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Center for Bionanoengineering and State Key Laboratory of Chemical Engineering,Zhejiang University,H

【出处】

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Fourth Symposium on Innovative Polymers for Controlled Deliv

【发表日期】

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2016年11期

【关键词】

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esterase responsive DNA release gene therapy

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　　Cationic polymers are widely used as nonvirial vectors to compact negatively charged DNA into DNA/polymer complexes (polyplexes)[1].However,the slow and incomplete release of DNA from the polyplexes intracellularly has been the bottleneck to effective gene expression[2].Inspired by recent research of stimuli-responsive nanocarriers for drug delivery[3],we reported an cellular esterase-responsive polyethyleneimine (ER-PEI) made from quaternary polyethyleneimine carrying N-propionic 4-acetoxybenzyl ester as an effective gene carrier.

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Esterase responsive charge-reversal vectors for gene delivery and therapy

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