Design and synthesis of amphiphilic core-shell nanoparticles with temperature sensitive-shell for co

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：daimao

【摘要】

：

The success of gene therapy greatly depends on suitable gene carriers that should provide safe,efficient and targeted delivery.Among various types of carries for gene delivery,polyethyleneimine (PEI)

【作者】

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Yam Chun Ho Yuen Shan Siu Cheng Hao Lee Pei Li

【机构】

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Department of Applied Biology and Chemical Technology,The Hong Kong Polytechnic Universtiy,Hung Hon,

【出处】

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The Third Symposium on Innovative Polymers for Controlled De

【发表日期】

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2014年6期

【关键词】

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temperature-responsive amphiphilic core-shell nanocarrier intracellular uptake

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　　The success of gene therapy greatly depends on suitable gene carriers that should provide safe,efficient and targeted delivery.Among various types of carries for gene delivery,polyethyleneimine (PEI) is considered to be an effective non-viral gene carrier because of its high complexing abilities with DNA and siRNA,as well as excellent transfection efficiency.However,the use of PEI for gene delivery has only achieved limited success owing to its cytotoxicity and broad size distribution of its polyplexes.

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Design and synthesis of amphiphilic core-shell nanoparticles with temperature sensitive-shell for co

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