• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Effect of Pb exposure on the expression of AD-related biomarkers and histone modification

Effect of Pb exposure on the expression of AD-related biomarkers and histone modification

来源 :环境与健康——从科研到政策国际论坛暨中国环境科学学会环境医学与健康分会2013年会 | 被引量 : 0次 | 上传用户：yucunjiang
【摘 要】
：
Objective To explore the potential mechanism of Pb on AD-related gene expression and the possible epigenetic modification effects in vitro.Methods SH-SY5Y cells were exposed to Pb for 48 h and the Aβ1
【作 者】
：
Hui Huang Wei Yuan Liuxin Cui 
【机 构】
：
Department of Environmental Health, College of Public Health, Zhengzhou University
【出 处】
：
环境与健康——从科研到政策国际论坛暨中国环境科学学会环境医学与健康分会2013年会
【发表日期】
：
2013年1期
【关键词】
：
Lead (Pb) β-amyloid (Aβ) Epigenetics Histonedeacetylase (HDAC) 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective To explore the potential mechanism of Pb on AD-related gene expression and the possible epigenetic modification effects in vitro.Methods SH-SY5Y cells were exposed to Pb for 48 h and the Aβ1-40 secreted into the medium was measured by ELISA.
其他文献
Ozone and daily mortality in 20 cities of East Asia
Objective To investigate the association between surface ozone pollution and daily mortality in 20 cities of East Asia, and to explore the potential seasonal pattern of this association.
会议
East AsiaOzoneMortalityTime-seriesSeason
Abnormal expression of heat shock protein 27 and 70 in cortex of rats with spatial learning and memo
Objectives Manganese (Mn) is an essential nutrient but excessive exposure to Mn is neurotoxic.The mechanism of Mn neurotoxicity is unclear.The present study was conducted to investigate the effect of
会议
manganeseMorris water mazeHsp27Hsp70learning and memory
Association of Tobacco Consumption, Polycyclic Aromatic Hydrocarbon Metabolites and Sperm Parameters
Objective To analyze the relationship of smoking behavior and polycyclic aromatic hydrocarbon exposure, as well as their effect on semen parameters.Methods Information of smoking behavior including hi
会议
smokingpolycyclic aromatic hydrocarbonsemenmaleenvironmental exposure
Developmental neurotoxicity of alumina nanoparticles: A study on offsprings developed by pregnant mi
In present study, we employed neurodevelopmental approaches to investigate the hypothesis that pregnancy exposure (nasal drip) to nano-sized alumina particles (13nm and 50nm) impairs fetal neurodevelo
会议
Application of health-based risk assessment in drinking water security
Objective To establish a method for drinking water security and health-based risk evaluation.Methods On-the-spot investigation and laboratory analysis were employed to understand Chengdu status of dri
会议
Health-based risk assessmentdrinking water securityapplication
Effect of PAEs on micronuclei rates in vicia faba root tip cells
Objective The mutagenicity of the different types of phthalate esters was studied.Methods Vicia faba root tip cells were used as experimental materials, and exposed to different concentrations of phth
会议
phthalate estersvicia fabaroot tip cellsmicronucleus test
Analysis of DNA Methylation profiles in low level of benzene exposure workers
Objectives To identify potential methylation biomarkers of low levels benzene exposure in occupationally exposed individuals and to elucidate mechanisms of benzene hematotoxicity.
会议
BenzenebiomarkersmethylationMicroarray analysis
The geographical distribution of the reference value of whole blood viscosity (5.75s-1) of young men
Objectives This paper aims at supplying a scientific basis for uniting the reference value standard of whole blood viscosity (5.75s-1) of Chinese young men.Methods A research is made about the relatio
会议
Whole blood viscosityReference valueGeographical elementsRegression analysis.
Toxicity of city PM2.5 on alveolar macrophages
Objectives to study the toxic effects of PM2.5 on alveolar macrophages (AM);Methods fine particulate matter in taiyuan city from a normal summer weather was used as experiment material.
会议
PM2.5Alveolar macrophagesToxicity
Health risk assessment of heavy metals based on GIS--A case study in the mining areas of an eastern
Objectives The present work is to identify the HM contaminant sites and assess the health risk due to the mining activities in an eastern city.Methods There is a closed Pb-Zn-Ag mine (A1) that had bee
会议
heavy metalhealth risk assessmentmining areaGIS