THE EFFECT OF CLOSING OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE ON IMMATURE RABBIT HEART PROTECT

• 作 者: LINRu;FANYong;
• 机 构: Affiliated Children's Hospital,School of Medicine,Zhejiang University,China
• 出 处: 第七届亚洲体外循环学术会议暨第三届全国体外循环学术会议
• 发表日期: 2007年期

　　Objective:To observe the cardioprotective effect of hyperkalemic cardioplegic solution enriched with either mitochondrial permeability transition pore inhibitor or potassium channel openers on rabbit immature heart subjected ischemia.Methods:Forty-five immature rabbit hearts were randomly divided into 5 groups.After control perfusion in modified Langendorff mode with Krebs-Henseleit bicarbonate buffer for 20 minutes,the isolated immature rabbit hearts were infused with 20ml different cardioplegia.