Tracing the dynamic changes of X chromosome inactivation during the human embryonic stem cells deriv

来源 :The 18th Congress of the International Federation of Associa | 被引量 : 0次 | 上传用户：zhangdeting

【摘要】

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【作者】

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Pingyuan Xie Guangxiu Lu Ge Lin

【机构】

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Institute of Reproductive & Stem Cell Engineering, Central South University, Changsha, 410078, China

【出处】

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The 18th Congress of the International Federation of Associa

【发表日期】

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2014年8期

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X chromosome inactivation (XCI) is required for dosage compensation of X-linked genes in human female cells.Several researah groups have described the promiscuous XCI status in long-term cultured female human embryonic stem cells (hESCs), which impact their utility.Here, we traced the XCI dynamic changes during the hESCs derivation and early culture.The results showed the female initial hESCs (～Passage 5) expressed XCI marker XIST and H3K27me3 dot and had a random inactivated X chromosome.

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